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Repercussions of COVID-19 pandemic on solid waste generation and management strategies

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1407-5

摘要：

• Implication of COVID-19 on medical waste and MSW generation is studied.

关键词： COVID-19     Medical waste     Personal protective equipment     Municipal solid waste     Waste management    

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How do digital technologies improve supply chain resilience in the COVID-19 pandemic?

《工程管理前沿（英文）》   页码 39-50 doi: 10.1007/s42524-022-0230-4

摘要： Digital technologies (DTs) can assist businesses in coping with supply chain (SC) disruptions caused by unpredictability, such as pandemics. However, the current knowledge of the relationship between DTs and supply chain resilience (SCR) is insufficient. This study draws on information processing theory to develop a serial mediation model to address this deficiency. We analyze a sample set consisting of 264 Chinese manufacturers. The empirical results reveal that digital supply chain platforms (DSCPs), as well as supply chain traceability (SCT) and supply chain agility (SCA), fully mediate the favorable association between DTs and SCR. Specifically, the four significant indirect paths indicated that firms can improve SCR only if they use DTs to directly or indirectly improve SCT and SCA (through DSCPs). Our study contributes to the literature on resilience by examining the possible mechanism of mediation through which DTs influence SCR. The findings also offer essential insights for firms to modify their digital strategies and thrive in a turbulent environment.

关键词： digital technologies     supply chain resilience     information processing theory     COVID-19     China    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

《医学前沿（英文）》 2022年 第16卷 第2期   页码 185-195 doi: 10.1007/s11684-021-0913-y

摘要： The record speed at which Chinese scientists identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and shared its genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19) diagnostics, drugs, and vaccines. It is unprecedented in pandemic control history to develop a dozen successful vaccines in the first year and to immunize over half of the global population in the second year, due to the efforts of the scientific community, biopharmaceutical industry, and regulatory agencies worldwide. The challenges are both great and multidimensional due to the rapid emergence of virus variants and waning of vaccine immunity. Vaccination strategies need to adapt to these challenges to keep population immunity above the herd immunity threshold, by increasing vaccine coverage, especially for older adults and young people, and providing timely booster doses with homologous or heterologous vaccine boosts. Further research should be undertaken to develop more effective vaccines against SARS-CoV-2 variants and to understand the best prime-boost vaccine combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19.

关键词： COVID-19     pandemics     SARS-CoV-2     vaccination    

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Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

《医学前沿（英文）》 2022年 第16卷 第6期   页码 984-990 doi: 10.1007/s11684-022-0930-5

摘要： Nonpharmaceutical interventions (NPIs) have been commonly deployed to prevent and control the spread of the coronavirus disease 2019 (COVID-19), resulting in a worldwide decline in influenza prevalence. However, the influenza risk in China warrants cautious assessment. We conducted a cross-sectional, sero-epidemiological study in Shandong Province, Northern China in mid-2021. Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains. A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic. The overall seroprevalence values against A/H1N1pdm09, A/H3N2, B/Victoria, and B/Yamagata were 17.8% (95% CI 16.2%–19.5%), 23.5% (95% CI 21.7%–25.4%), 7.6% (95% CI 6.6%–8.7%), and 15.0 (95% CI 13.5%–16.5%), respectively, in the study period. The overall vaccination rate was extremely low (2.6%). Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals (P < 0.001). Notably, the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic ( P < 0.01). Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China.

关键词： influenza virus     seroprevalence     antibody     COVID-19     cross-sectional study    

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全球旅行和接触限制对减缓COVID-19 疫情大流行作用的评估 Article

赖圣杰, Nick W. Ruktanonchai, Alessandra Carioli, Corrine W. Ruktanonchai, Jessica R. Floyd, Olivia Prosper, 张弛, 杜向军, 杨维中, Andrew J. Tatem

《工程（英文）》 2021年 第7卷 第7期   页码 914-923 doi: 10.1016/j.eng.2021.03.017

摘要：

为了减缓新冠病毒肺炎（COVID-19）疫情的大流行，全球已广泛实施了旅行限制和保持社交距离的措施，但这些干预措施在不同地区和时间方面的有效性尚待深入研究135个国家或地区手机定位数据获得的人口流动指标，我们构建了一个元人口流行病学模型（metapopulation epidemiological model），用于评估全球旅行和接触限制对遏制不同地区COVID-19-19传播的影响。研究发现，如果未采取这些干预措施，截至2020年5月31日，研究地区（135个国家或地区）的累计COVID-19病例数可能已增加97倍（四分位距为79~116）。

关键词： COVID-19     大流行     人口流动     旅行限制     保持社交距离    

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Innovation-driven trend shaping COVID-19 vaccine development in China

《医学前沿（英文）》 doi: 10.1007/s11684-023-1034-6

摘要： Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and mutation, with several innovative platforms, which provides various technical means in this persisting combat. Derived from collaborated researches, vaccines based on the spike protein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19. Herein, we outline representative vaccines in multiple routes, while the merits and plights of the existing vaccine strategies are also summarized. Likewise, new technologies may provide more potent or broader immunity and will contribute to fight against hypermutated SARS-CoV-2 variants. All in all, with the ultimate aim of delivering robust and durable protection that is resilient to emerging infectious disease, alongside the traditional routes, the discovery of innovative approach to developing effective vaccines based on virus properties remains our top priority.

关键词： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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A review of the safety and efficacy of current COVID-19 vaccines

《医学前沿（英文）》 2022年 第16卷 第1期   页码 39-55 doi: 10.1007/s11684-021-0893-y

摘要： Vaccination is the most effective and feasible way to contain the coronavirus disease 2019 (COVID-19) pandemic. The rapid development of effective COVID-19 vaccines is an extraordinary achievement. This study reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed COVID-19 vaccines and discussed the challenges and prospects of the vaccine-based approaches in a global crisis. Overall, most of the current vaccines have shown safety and efficacy/effectiveness during actual clinical trials or in the real-world studies, indicating a development of pandemic control. However, many challenges are faced by pandemic control in terms of maximizing the effect of vaccines, such as rapid vaccine coverage, strategies to address variants with immune escape capability, and surveillance of vaccine safety in the medium- and long-terms.

关键词： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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Digital twin for healthy indoor environment: A vision for the post-pandemic era

《工程管理前沿（英文）》 2023年 第10卷 第2期   页码 300-318 doi: 10.1007/s42524-022-0244-y

摘要： Indoor environment has significant impacts on human health as people spend 90% of their time indoors. The COVID-19 pandemic and the increased public health awareness have further elevated the urgency for cultivating and maintaining a healthy indoor environment. The advancement in emerging digital twin technologies including building information modeling (BIM), Internet of Things (IoT), data analytics, and smart control have led to new opportunities for building design and operation. Despite the numerous studies on developing methods for creating digital twins and enabling new functionalities and services in smart building management, very few have focused on the health of indoor environment. There is a critical need for understanding and envisaging how digital twin paradigms can be geared towards healthy indoor environment. Therefore, this study reviews the techniques for developing digital twins and discusses how the techniques can be customized to contribute to public health. Specifically, the current applications of BIM, IoT sensing, data analytics, and smart building control technologies for building digital twins are reviewed, and the knowledge gaps and limitations are discussed to guide future research for improving environmental and occupant health. Moreover, this paper elaborates a vision for future research on integrated digital twins for a healthy indoor environment with special considerations of the above four emerging techniques and issues. This review contributes to the body of knowledge by advocating for the consideration of health in digital twin modeling and smart building services and presenting the research roadmap for digital twin-enabled healthy indoor environment.

关键词： digital twin     healthy indoor environment     building information modeling     occupant–building interaction     COVID-19    

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COVID-19: why not learn from the past?

《医学前沿（英文）》 2021年 第15卷 第5期   页码 776-781 doi: 10.1007/s11684-021-0883-0

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

《医学前沿（英文）》 2022年 第16卷 第5期   页码 815-826 doi: 10.1007/s11684-021-0891-0

摘要： Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL) due to their reliable efficacy, manageable safety, high accessibility, and convenience for use. Still, no guidelines or consensus focusing on oral drug therapies for BCL is available. To provide a reference of oral agent-based treatment for mature BCL, a panel of experts from the Lymphocyte Disease Group, Chinese Society of Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China, combined with the latest authoritative guidelines in the world and current research reports. This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients. With the deepening of research and the development of standardized clinical applications, oral medications will bring better treatment to BCL patients, enabling more patients to benefit from them.

关键词： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

《医学前沿（英文）》 2023年 第17卷 第3期   页码 576-580 doi: 10.1007/s11684-023-0991-0

摘要： Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

关键词： variant    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

《医学前沿（英文）》 2022年 第16卷 第1期   页码 111-125 doi: 10.1007/s11684-021-0854-5

摘要： The coronavirus disease 2019 (COVID-19) has spread globally. Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injury caused by specific subtype especially chronic hepatitis B (CHB) with COVID-19 has not been elucidated. In this multi-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients with COVID-19 were propensity score matched at an approximate ratio of 3:1 on the basis of age, sex, and comorbidities. Demographic characteristics, laboratory examinations, disease severity, and clinical outcomes were compared. Furthermore, univariable and multivariable logistic and Cox regression models were used to explore the risk factors for disease severity and mortality, respectively. A higher proportion of CHB patients (30 of 109 (27.52%)) developed into severe status than non-CHB patients (17 of 327 (5.20%)). In addition to previously reported liver impairment markers, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin, we identified several novel risk factors including elevated lactate dehydrogenase (≥245 U/L, hazard ratio (HR) = 8.639, 95% confidence interval (CI) = 2.528–29.523; P <0.001) and coagulation-related biomarker D-dimer (≥0.5 μg/mL, HR= 4.321, 95% CI= 1.443–12.939; P = 0.009) and decreased albumin (<35 g/L, HR= 0.131, 95% CI= 0.048–0.361; P <0.001) and albumin/globulin ratio (<1.5, HR= 0.123, 95% CI= 0.017–0.918; P = 0.041). In conclusion, COVID-19 patients with CHB were more likely to develop into severe illness and die. The risk factors that we identified may be helpful for early clinical surveillance of critical progression.

关键词： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak

《医学前沿（英文）》 2023年 第17卷 第3期   页码 562-575 doi: 10.1007/s11684-022-0977-3

摘要： The Omicron family of SARS-CoV-2 variants are currently driving the COVID-19 pandemic. Here we analyzed the clinical laboratory test results of 9911 Omicron BA.2.2 sublineages-infected symptomatic patients without earlier infection histories during a SARS-CoV-2 outbreak in Shanghai in spring 2022. Compared to an earlier patient cohort infected by SARS-CoV-2 prototype strains in 2020, BA.2.2 infection led to distinct fluctuations of pathophysiological markers in the peripheral blood. In particular, severe/critical cases of COVID-19 post BA.2.2 infection were associated with less pro-inflammatory macrophage activation and stronger interferon alpha response in the bronchoalveolar microenvironment. Importantly, the abnormal biomarkers were significantly subdued in individuals who had been immunized by 2 or 3 doses of SARS-CoV-2 prototype-inactivated vaccines, supporting the estimation of an overall 96.02% of protection rate against severe/critical disease in the 4854 cases in our BA.2.2 patient cohort with traceable vaccination records. Furthermore, even though age was a critical risk factor of the severity of COVID-19 post BA.2.2 infection, vaccination-elicited protection against severe/critical COVID-19 reached 90.15% in patients aged ≥ 60 years old. Together, our study delineates the pathophysiological features of Omicron BA.2.2 sublineages and demonstrates significant protection conferred by prior prototype-based inactivated vaccines.

关键词： SARS-CoV-2     COVID-19     host response     bronchoalveolar lavage fluid (BALF)    

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Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

《医学前沿（英文）》 2020年 第14卷 第2期   页码 210-214 doi: 10.1007/s11684-020-0757-x

摘要： In December 2019, an outbreak of novel coronavirus (2019-nCoV) occurred in Wuhan, Hubei Province, China. By February 14, 2020, it has led to 66 492 confirmed patients in China and high mortality up to ~2.96% (1123/37 914) in Wuhan. Here we report the first family case of coronavirus disease 2019 (COVID-19) confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid (SHL). This report describes the identification, diagnosis, clinical course, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19, and warrants further clinical trials.

关键词： novel coronavirus (2019-nCoV)     COVID-19     Chinese traditional patent medicine     Shuanghuanglian oral liquid    

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COVID-19 疫情背景下的医院人工智能快速布局和发展战略探讨

陈新华,蒋建文,周华,谢海洋,周琳,郭丹婧,薛晨,朱威威,周建英,郑树森

《中国工程科学》 2020年 第22卷 第2期   页码 130-137 doi: 10.15302/J-SSCAE-2020.02.021

摘要：

本文旨在开展新型冠状病毒肺炎（COVID-19）疫情背景下医院人工智能（AI）应用的宏观探讨，以期推动我国医院AI应用的顶层设计和快速布局COVID-19疫情发生以来，中国以举国之力实施疫情防控阻击战，同步以捐赠物资、派遣医疗队、分享医疗诊治经验和高科技手段等方式开展全球抗疫协作。在抗击COVID-19疫情的过程中，一线医疗工作展示了有关医疗AI应用丰富且宝贵的经验，体现了AI在抗疫前线发挥的突出作用，表明了我国医院AI建设需求的迫切性和战略性。

关键词： 医院建设     新型冠状病毒肺炎     人工智能     应用现状     发展方向    

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标题 作者 时间 类型 操作

Repercussions of COVID-19 pandemic on solid waste generation and management strategies

期刊论文

How do digital technologies improve supply chain resilience in the COVID-19 pandemic?

期刊论文

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

期刊论文

Seroprevalence of influenza viruses in Shandong, Northern China during the COVID-19 pandemic

期刊论文

全球旅行和接触限制对减缓COVID-19 疫情大流行作用的评估

赖圣杰, Nick W. Ruktanonchai, Alessandra Carioli, Corrine W. Ruktanonchai, Jessica R. Floyd, Olivia Prosper, 张弛, 杜向军, 杨维中, Andrew J. Tatem

期刊论文

Innovation-driven trend shaping COVID-19 vaccine development in China

期刊论文

A review of the safety and efficacy of current COVID-19 vaccines

期刊论文

Digital twin for healthy indoor environment: A vision for the post-pandemic era

期刊论文

COVID-19: why not learn from the past?

期刊论文

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

期刊论文

Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

期刊论文

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center

期刊论文

Host protection against Omicron BA.2.2 sublineages by prior vaccination in spring 2022 COVID-19 outbreak

期刊论文

Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

期刊论文

COVID-19 疫情背景下的医院人工智能快速布局和发展战略探讨

陈新华,蒋建文,周华,谢海洋,周琳,郭丹婧,薛晨,朱威威,周建英,郑树森

期刊论文